Boronic acid derivatives
Cayman Chemical CAY10486 Fatty Acids and Deriv
An inhibitor of ACAT; inhibits human ACAT-1 and ACAT-2 (IC50s = ~60 µM for both); inhibits copper-mediated oxidation of LDL by about 20% at 3 µM
Cayman Chemical 19 SHETE Fatty Acids and Deriv
Potent vasodilator of renal preglomerular vessels; 70% of the metabolite composition of arachidonic acid by CYP2E1; stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule
Cayman Chemical CAY10562 Fatty Acids and Deriv
A S-nitrosothiol that acts as an NO donor under acidic conditions; decomposes with a half-life of 6 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C; relaxes phenylephrine-constricted rat aortic strips 35% and 8% at pH 6.0 and 7.4, respectively
Aobchem 3-(Cyclopropylaminocarbonyl)phenylboronic acid, AOBCHEM USA 11442-5G. 850567-23-6. MFCD04115694
3-(Cyclopropylaminocarbonyl)phenylboronic acid, AOBCHEM USA 11442-5G. 850567-23-6. MFCD04115694
Cayman Chemical CAY10462 Fatty Acids and Deriv
A selective inhibitor of the 20-HETE synthase CYP4A11 (IC50 = 8.8 nM in human renal microsomes); 200-fold less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes
Cayman Chemical CAY10602 Fatty Acids and Deriv
A SIRT1 activator; inhibits LPS-induced TNF-α release in THP-1 cells at 20 and 60 µM; decreases the expression of GPX4, SLC7A11, and SLC3A2, as well as increases the levels of iron and MDA, in A549, MDA-MB-231, and Hs 578T cells at 5 µM; reduces oleic acid-induced apoptosis and lipid accumulation in HepG2 cells when used at a concentration of 20 µM
Cayman Chemical CAY10487 Fatty Acids and Deriv
An antioxidant with anti-atherogenic activity; inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity; dietary administration (0.05%) reduces the percent area occupied by the atherosclerotic lesion in rabbits to 16.1% from 53.5% in control rabbits; inhibits copper-mediated oxidation of LDL by ~75% at 2 µM
Cayman Chemical CAY10448 Fatty Acids and Deriv
An iodinated nonivamide; a TRPV1 antagonist (IC50 = ~10 nM)
Cayman Chemical 17 SHDHA Fatty Acids and Deriv
A hydroxy fatty acid formed from DHA by 15-LO and is a precursor to 17(S)-resolvins; inhibits platelet 12-LO (IC50 = 0.4 μM); inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM); inhibits NLRP3 inflammasome formation induced by homocysteine in podocytes at 100 nM
Cayman Chemical CAY10562 Fatty Acids and Deriv
A S-nitrosothiol that acts as an NO donor under acidic conditions; decomposes with a half-life of 6 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C; relaxes phenylephrine-constricted rat aortic strips 35% and 8% at pH 6.0 and 7.4, respectively